Her part in Ridley Scott's 1979 film Alien as the sole survivor, Lieutenant Ripley, ensured her role in the sequels Aliens, Alien3 and Alien: Resurrection. Many of her roles since have been in knowing reference to the tough character of Ripley.
- 1979: Alien
- 1984: Ghostbusters
- 1989: Ghostbusters II
- 1988: Gorillas in the Mist: The Story of Dian Fossey
- 1992: 1492: Conquest of Paradise
- 1997: The Ice Storm
- 1999: Galaxy Quest