Holmes fought on HBO several times, made several television commercials (Including one with Sugar Ray Leonard for Ford Trucks), wrote a biography, appeared in many boxing video games, including some that bear his name, owns several businesses in the Easton Pennsylvania area, and is still boxing as a professional. His nickname is The Easton Assassin and he is regarded by many boxing fans as one of the top ten world Heavyweight champions in history.
Among his victims were the following world champions:
- Muhammad Ali (In Ali's last bout)
- Trevor Berbick
- Ray Mercer
- Ken Norton
- Ossie Ocasio
- James Smith
- Leon Spinks
- Mike Weaver
- Tim Witherspoon
He seems to love his fame and he is a good autographs signer.