KidneyThe kidneys are the most important excretory organ in vertebrates. Medical terms related to the kidneys either involve renal or nephro-. Nephrology is the study of the kidneys.
|Table of contents|
2 Basic anatomy
3 Diseases and disorders
4 Dialysis and kidney transplants
5 See also
The major functions of the kidney are to filter wastes from the bloodstream and to regulate the pH, serum osmolality and blood pressure (and secondarily, the volume of the blood). The wastes are concentrated to form urine which is passed on to the bladder via the ureter.
The kidney also serves an endocrine function by secreting erythropoietin, a hormone that regulates red blood cell production in the bone marrow. Other hormones produced by the kidneys are renin, active form of vitamin D - 1,25-dihydroxycholecalciferol (calcitriol) and prostaglandins.
In humans the kidneys are the two organs that are located in the posterior part of the abdomen, on either side of the spine just below the liver and spleen on the right and left sides of the body respectively. Superior to each kidney is an adrenal gland (also called the suprarenal gland).
- Kidneys viewed from behind with spine removed
The upper parts of the kidneys are protected somewhat by the eleventh and twelfth ribs, and each whole kidney is surrounded by two layers of fat, the perirenal fat and the pararenal fat, which help to cushion it.
The basic functional unit of the kidney is the nephron, of which there are more than a million in each normal adult kidney. Nephrons regulate water and soluble substances (especially ions) in the body by filtering it all out first, reabsorbing what should be kept and excreting the rest. They use countercurrent exchange mechanisms. A nephron consists of a Bowman's capsule, a proximal convoluted tubule, a loop of Henle and a distal convoluted tubule which empties the urine into a collecting duct.
- renal capsule: The membranous covering of the kidney.
- cortex: The outer layer over the internal medulla. It contains blood vessels, glomeruli (which are the kidneys' "filters") and urine tubes and is supported by a fibrous matrix.
- hilus: The opening in the middle of the concave medial border for nerves and blood vessels to pass into the renal sinus.
- renal column: The structures which support the cortex. They consist of lines of blood vessels and urinary tubes and a fibrous material.
- renal sinus: The cavity which houses the renal pyramid.
- calyces: The recesses in the internal medulla which hold the pyramids. They are used to subdivide the sections of the kidney. (singular - calyx)
- papillae: The small conical projections along the wall of the renal sinus. They have openings through which urine passes into the calyces. (singular - papilla)
- pyramids: The conical segments within the internal medulla. They contain the secreting apparatus and tubules and are also called malpighian pyramids.
- renal artery: Two renal arteries come from the aorta, each connecting to a kidney. The artery divides into five branches, each of which leads to a ball of capillaries. The arteries supply (unfiltered) blood to the kidneys. The left kidney receives about 60% of the renal bloodflow.
- renal vein: The filtered blood returns to circulation through the renal veins which join into the inferior vena cava.
- renal pelvis: Basically just a funnel, the renal pelvis accepts the urine and channels it out of the hilus into the ureter.
- ureter: A narrow tube 40 cm long and 4 mm in diameter. Passing from the renal pelvis out of the hilus and down to the bladder. The ureter carries urine from the kidneys to the bladder.
Diseases and disorders
Congenital diseases of the kidneys
Aquired diseases of the kidneys
The basic means to assess excretory function of the kidneys is glomerular filtration rate; usually a creatinine clearance test is performed
Dialysis and kidney transplants
Generally, one can live fine with just one kidney. If both kidneys don't function properly, dialysis is performed, where the blood is filtered outside of the body. Kidney transplants are now also quite common. The first successful such transplant was announced on March 4, 1954 by Peter Bent Brigham Hospital in Boston.