- February 9 - Gregory XV is elected pope.
- February 17 - Miles Standish is appointed as first commander of Plymouth Colony
- March 22 - The Pilgrims of Plymouth Colony sign a peace treaty with Massasoit of the Wampanoags.
- March 16 - Samoset , a Mohegan, visits the settlers of Plymouth Colony and greets them, "Welcome, Englishmen! My name is Samoset."
- April 5 - The Mayflower sets sail from Plymouth on a return trip to Great Britain.
- The Swedish city of Gothenburg is founded by Gustavus Adolphus