- February 8 - Mary, Queen of Scots is executed.
- July 22 - Colony of Roanoke: A group of English settlers arrive on Roanoke Island off of North Carolina to re-establish the deserted colony.
- October 20 - Battle of Coutras - Huguenot forces under Henry of Navarre defeat Royalist forces under Anne, Duc de Joyeuse, favorite of King Henry. Joyeuse is killed.
- The Rose (theatre) is founded in London by Philip Henslowe.
- January 6 - Gaspar de Guzman, Count of Olivares, Duke of San Lucar
- August 18 - Virginia Dare, granddaughter of Gov. John White of the Colony of Roanoke, becomes the first English child born in the Americas.