- April 27 - Cebu City is established becoming the first Spanish settlement in Philippines.
- August 28 - St. Augustine, Florida (named after St. Augustine), established. It is the oldest remaining European settlement in the United States.
- September 8 - The Knights of Malta lift the Turkish siege of Malta (siege started on May 18).
- Miguel López de Legaspi founds San Miguel, the first Spanish settlement in the Philippines
- Russia, beginning of the Opritchtina