- January 15 - Elizabeth I of England is crowned in Westminster Abbey.
- April 3 - Peace of Cateau Cambrésis - France makes peace with England and Spain. France gives up most of its gains in Italy (including Savoy), keeping only Saluzzo, but keeps the three Lorraine bishoprics of Metz, Toul, and Verdun, and the formerly English town of Calais.
- July 10 - Francis II becomes King of France following the death of his father, Henry II in a jousting accident.
- End of the Italian Wars.