- April 22 - Henry VIII becomes King of England on the death of his father, Henry VII
- April 27 - Pope Julius II places Venice under interdict.
- May 14 - Battle of Agnadello - French forces defeat the Venetians.
- June 24 - King Henry VIII of England's and Queen consort's Catherine of Aragon coronation ceremony.
- July 10 - John Calvin, founder of calvinism
- Nicholas Bacon - English politician
- Jane Seymour, later third Queen consort of Henry VIII of England.