- January 2 - Boabdil, the last Moorish King of Granada, surrenders his city to the army of Ferdinand and Isabella after a lengthy siege.
- March 30 - Ferdinand and Isabella sign a decree aimed at expelling all Jews from Spain unless they convert to Roman Catholicism.
- August 3 - Christopher Columbus first sails to the Americas
- August 3 - The Jews were expelled from Spain
- October 12 - Christopher Columbus's expedition makes landfall in the Caribbean. The Italian explorer believes he has reached East Asia.
- October 28 - Christopher Columbus lands in Cuba.
- Moors driven from Spain
- Casimir IV Jagiello of Jagiello Royal House ends reign. (1427-1492),